Cooling Solutions

2-Isopropyl-N,2,3-trimethylbutyramide WS-23 Cooling Agent

CAS: 51115-67-4
Purity: ≥99.0%
FEMA: 3804
JECFA: 1595
Description: 2-Isopropyl-N,2,3-trimethylbutyramide, also known as Cooling Agent WS-23, CAS 51115-67-4, is a clean fast-onset cooling ingredient for beverage, confectionery, chewing gum and others formulations.
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2-Isopropyl-N,2,3-trimethylbutyramide WS-23 | CAS 51115-67-4 Clean Cooling Ingredient

2-Isopropyl-N,2,3-trimethylbutyramide, commonly known as Cooling Agent WS-23, is a fast-onset clean cooling ingredient used across flavor, beverage, confectionery, chewing gum, oral care and personal care formulations. Compared with traditional menthol, WS-23 provides a refreshing cooling sensation with minimal mint character, making it suitable for products where formulators require precise cooling without a dominant peppermint profile.

This technical page is designed for R&D teams, flavor developers and purchasing managers who need to confirm the exact chemical identity of WS-23, review CAS information, verify documentation support and evaluate its suitability for practical formulation systems.

1. What is 2-Isopropyl-N,2,3-trimethylbutyramide?

2-Isopropyl-N,2,3-trimethylbutyramide is the formal chemical name associated with Cooling Agent WS-23. It belongs to the WS-series of synthetic cooling compounds and is used to create a clean and immediate cooling perception in flavor systems. Its cooling effect is valued for rapid onset, low mint note and compatibility with fruit, citrus, tea, mint and sweet confectionery profiles.

Buyers often search this chemical name to verify raw material identity, cross-reference the CAS number or prepare technical documentation for internal QA/QC, regulatory and formulation evaluation.

2. Chemical Identity and Synonyms

Item	Information
Chemical Name	2-Isopropyl-N,2,3-trimethylbutyramide
Common Name	Cooling Agent WS-23
CAS No.	51115-67-4
FEMA No.	3804
JECFA No.	1595
Molecular Formula	C10H21NO
Molecular Weight	171.28
Synonyms	N,2,3-Trimethyl-2-isopropylbutanamide; Methyl diisopropyl propionamide; 2-Isopropyl-N,2,3-trimethylbutanamide
Typical Appearance	White crystalline powder
Typical Application	Beverages, hard candies, chewing gums, oral care and clean cooling flavor systems

2-Isopropyl-N,2,3-trimethylbutyramide WS-23 cooling agent for beverages, confectionery, chewing gum and oral care applications

3. Why Formulators Choose WS-23

WS-23 is frequently selected when a formulation needs a crisp and immediate cooling sensation without introducing a heavy herbal or peppermint note. This differentiates it from natural menthol, which can bring a distinct mint aroma, bitterness or burning sensation at higher dosage levels.

Fast-onset cooling: Suitable for products targeting a sharp and immediate sensory impact upon consumption.

Low flavor interference: Supports fruit, citrus and sweet profiles without pushing the formulation toward a medicinal direction.

Clean sensory profile: Useful for applications requiring refreshing coolness with limited camphoraceous or menthol-like aftertaste.

Formulation flexibility: WS-23 can be used as a standalone cooling agent or as the front-end cooling component in a blended cooling system.

4. WS-23 Sensory Profile and Formulation Value

Formulation Factor	WS-23 Performance	Buyer Evaluation Point
Cooling Onset	Fast and noticeable cooling impact	Evaluate the first 10-60 seconds of sensory response in the final product.
Cooling Character	Clean, fresh and low mint character	Check whether it interferes with delicate fruit, tea or sweet flavor notes.
Cooling Duration	Short-to-medium cooling duration	For prolonged cooling, consider blending with WS-12 or WS-3.
Carrier Compatibility	Compatible with selected flavor carrier systems	Confirm solubility, clarity, precipitation risk and storage stability in the final formula.
Flavor Balance	Creates cooling without a heavy menthol bite	Adjust dosage together with sweetness, acidity and target aroma profile.

5. Application Notes for Beverage, Candy, Gum and Oral Care

While WS-23 can be used across different systems, optimal performance depends on product format, carrier selection, processing temperature and dosage. The following technical notes are designed to guide practical lab evaluation.

Application	Why WS-23 Works	What to Validate
Clear Beverages & Functional Waters	Provides fast, clean cooling with limited mint note.	Clarity, haze, precipitation, pH stability, carrier compatibility and storage stability.
Hard Candy & Lozenges	Supports immediate cooling impact when the product contacts the palate.	Addition stage, thermal processing loss, cooling retention and final sensory balance.
Chewing Gum	Provides fast first-bite cooling and can work as the front-end trigger in a cooling blend.	Release curve, gum base compatibility, flavor oil incorporation and chewing duration.
Oral Care & Breath Freshening	Creates a fresh cooling effect without relying only on high menthol levels.	Cooling strength, irritation potential, sweetness balance and user comfort.

6. Formulation Validation: What Buyers Should Test

In professional R&D, WS-23 should not be evaluated only by its certificate of analysis. Final performance should be validated in the customer's specific application system, especially for clear beverages, high-temperature confectionery and prolonged-chew gum products.

Solubility and dispersion: Confirm whether WS-23 dissolves or disperses properly in the selected carrier system.

Clarity and precipitation: For transparent liquids, monitor haze, sedimentation and cold-storage stability over time.

Sensory onset and duration: Evaluate how quickly the cooling activates and how long it remains noticeable.

Flavor interaction: Check whether WS-23 mutes or distorts citrus, berry, tea, mint or herbal notes.

Processing compatibility: Review mixing temperature, point of addition and thermal residence time.

7. When to Use WS-23 Alone and When to Blend

WS-23 is a strong choice for fast and direct cooling. When an application requires a longer cooling tail, formulators can build a layered sensory curve by combining WS-23 with other cooling agents.

Formulation Goal	Recommended Direction	Technical Logic
Fast clean cooling	Use WS-23 as the primary cooling agent	Suitable for beverages and fruit-flavored applications requiring immediate impact.
Longer-lasting cooling	Blend WS-23 with WS-12	WS-23 provides the initial impact, while WS-12 supports the long cooling curve.
Stronger mint impact	Blend WS-23 with menthol, WS-3 or WS-5	Useful for oral care, breath freshening and strong mint formulations.
Cleaner fruit refreshment	Use controlled WS-23 dosage	Helps create a chilled beverage perception without adding peppermint character.

8. Available Documents and Quality Support

Xi'an Taima Biological Engineering Co., Ltd. supplies Cooling Agent WS-23 for formulation development and B2B procurement. Documentation support is important for food, flavor, beverage, confectionery and oral care applications.

COA: Certificate of Analysis for batch-specific quality and purity review.

SDS: Safety Data Sheet for handling, storage and safety communication.

TDS: Technical Data Sheet for physical properties and formulation evaluation.

Allergen Statement: Available when required for customer documentation review.

Halal / Kosher: Available where applicable or upon customer request.

9. Why Partner with Xi'an Taima?

Sourcing WS-23 is not only about matching a CAS number. Advanced formulation work requires a supplier that can support quality consistency, technical discussion, documentation preparation and export communication.

Cooling ingredient focus: Supply and support for WS-23, WS-3, WS-5, WS-12 and customized cooling blends.

Application-oriented communication: Support for beverage, confectionery, chewing gum, oral care and flavor systems.

Sample and pilot support: Samples are available for lab evaluation before bulk purchase.

B2B export support: Packaging, logistics and documentation communication for international buyers.